ROLE OF UDP-GLUCURONOSYLTRANSFERASE 1A1 IN THE METABOLISM AND PHARMACOKINETICS OF SILYMARIN FLAVONOLIGNANS IN PATIENTS WITH HCV AND NAFLD

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD

Silymarin is the most commonly used herbal medicine by patients with chronic liver disease.Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation.The aims of this investigation were: (1) to determine the association of UGT1A1*28 polymorphism with the area under the plasma concentration-time curves (AUCs) for silyb

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Peripheral-Free Calibration Method for Redundant IMUs Based on Array-Based Consumer-Grade MEMS Information Fusion

The MEMS array-based inertial navigation module (M-IMU) reduces the measurement singularities Totes of MEMS sensors by fusing multiple data processing to improve its navigation performance.However, there are still existing random and fixed errors in M-IMU navigation.The calibration method calibrates the fixed error parameters of M-IMU to further im

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Taming the beast: rabies control in the cradle of mankind

Between 2006 and 2012, a rabies control programme has been conducted in the area of Lake Turkana in northern Kenya.Spatial data obtained for this project were analysed with the aim of vibrators-kits assessing the importance of dog home ranges with the view of possible overlapping between dog populations from adjacent localities.In contrast to our e

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Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring

An innovative method based on inductively coupled plasma mass spectrometry (ICP-MS) was developed to quantify the time-dependent systemic redistribution pattern of pulmonary-deposited crystalline silica particles by measuring silicon (Si) levels in the lungs, Bookcases distal organs, and biological fluids.The method was applied in a murine model an

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